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The Long-Term Follow-Up Study is designed to examine many different aspects of healthcare for people treated for cancer or similar illnesses. It is one of the largest epidemiological investigations of late effects outcomes of its kind.

Participants are individuals diagnosed with cancer between 1970 and 1999, before reaching the age of 21. The study consist of approximately 24,000 survivors and an additional 5,000 siblings of survivors who serve as the comparison group.